1-Phenyl-1,2,3,4-Tetrahydroisoquinoline CAS 22990-19-8 Purity ≥98.5% (HPLC) Factory

Short Description:

Name: 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline

CAS: 22990-19-8

Appearance: White Crystal Powder

Purity: ≥98.5% (HPLC)

Assay: 98.5%~101.0% (on the dried basis)

Intermediate of Solifenacin Succinate (CAS: 242478-38-2) in the treatment of Overactive Bladder (Pollakiuria)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

22990-19-8 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 1-Phenyl-1,2,3,4-Tetrahydro-Isoquinoline (CAS: 22990-19-8) with high quality, intermediate of Solifenacin Succinate (CAS 242478-38-2) in the treatment of Overactive Bladder (Pollakiuria). Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years. Ruifu Chemical can provide competitive price, excellent service. Purchase 1-Phenyl-1,2,3,4-Tetrahydro-Isoquinoline or other products, please contact us by e-mail: alvin@ruifuchem.com

Intermediates of Solifenacin Succinate:

Commercial Supply Solifenacin Succinate Intermediates:
Solifenacin Succinate CAS: 242478-38-2
(R)-(-)-3-Quinuclidinol CAS: 25333-42-0
(S)-(+)-3-Quinuclidinol CAS: 34583-34-1
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Phenyl-1,2,3,4-Tetrahydro-Isoquinoline CAS: 22990-19-8
(S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline CAS: 118864-75-8

22990-19-8 - Chemical Properties:

Chemical Name	1-Phenyl-1,2,3,4-Tetrahydroisoquinoline
Synonyms	1,2,3,4-Tetrahydro-1-Phenylisoquinoline
CAS Number	22990-19-8
Melting Point	98.0 to 102.0℃
Density	1.065±0.06 g/cm3
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C15H15N
Molecular Weight	209.29
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

22990-19-8 - Specifications:

Item	Specifications
Appearance	White Crystal Powder
Single Impurity	≤0.20%
Melting Point	98.0~102.0℃
Loss on Drying	≤0.50%
Purity	≥98.5% (HPLC)
Assay	98.5%~101.0% (on the dried basis)
Test Standard	Enterprise Standard

22990-19-8 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃), well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

22990-19-8 - Advantages:

22990-19-8 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

22990-19-8 - Risk and Safety:

Hazard Symbols Xn - Harmful
Risk Codes 22 - Harmful if swallowed

22990-19-8 - Application:

Solifenacin Succinate API (CAS: 242478-38-2) is an antimuscarinic medication that is used to treat an overactive bladder causing symptoms of frequency, urgency, or incontinence. Solifenacin Succinate is an M3 muscarinic receptor antagonist that was developed and launched for the treatment of overactive bladder (pollakiuria) in Europe. The synthesis of Solifenacin Succinate involves the preparation of racemic 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline via cyclization of N-(2-phenylethyl)benzamide, and subsequent reaction with ethyl chloroformate and transesterification with (R)- 3-Quinuclidinol. Chiral chromatography affords the isolation of the desired diastereomer. Alternatively, 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline may be subjected to optical resolution with (+)-Tartaric Acid prior to treatment with ethyl chloroformate and subsequent transesterification.